HTML Code

<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="utf-8">
  <title>terminate after reply</title>
</head>
<body>
  <button id="run" type="button">Ping then terminate</button>
  <pre id="out">Waiting...</pre>
  <script>
    var code = "self.onmessage = function () { self.postMessage('pong'); };";
    var url = URL.createObjectURL(new Blob([code], { type: "application/javascript" }));
    var worker = new Worker(url);
    var out = document.getElementById("out");

    worker.onmessage = function (e) {
      out.textContent = e.data + "\n(terminated)";
      worker.terminate();
      URL.revokeObjectURL(url);
    };

    document.getElementById("run").addEventListener("click", function () {
      worker.postMessage("ping");
    });
  </script>
</body>
</html>

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Worker.terminate() — after reply (Try It)