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<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="utf-8">
  <title>\D non-digit</title>
</head>
<body>
  <h1>Match non-digits</h1>
  <pre id="out"></pre>
  <script>
    var mixed = "abc123def456";
    var letters = mixed.match(/\D+/g);
    document.getElementById("out").textContent =
      JSON.stringify(letters) + "\n" +
      /\D/.test("123") + "\n" +
      /\D/.test("a1");
  </script>
</body>
</html>

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JavaScript RegExp \d — \D non-digit (Try It)