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<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="utf-8">
  <title>Clear with firstChild</title>
</head>
<body>
  <div id="box"><span>A</span><span>B</span><span>C</span></div>
  <pre id="out"></pre>
  <script>
    var box = document.getElementById("box");
    while (box.firstChild) {
      box.removeChild(box.firstChild);
    }
    document.getElementById("out").textContent = String(box.firstChild);
  </script>
</body>
</html>

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Node.firstChild — clear children (Try It)