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<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="utf-8">
  <title>document.append multi</title>
</head>
<body>
  <pre id="out"></pre>
  <script>
    var doc = new Document();
    var html = doc.createElement("html");
    var body = doc.createElement("body");
    var span = doc.createElement("span");
    html.append(body);
    body.append("Hello ", span, "!");
    doc.append(html);
    document.getElementById("out").textContent = body.textContent;
  </script>
</body>
</html>

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Document.append — build tree with multiple append (Try It)