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<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="utf-8">
  <title>jQuery :not(.active) demo</title>
  <style>
    body { font-family: sans-serif; padding: 16px; }
    ul { list-style: none; padding: 0; }
    li { padding: 8px 12px; margin: 4px 0; background: #f1f5f9; border-radius: 6px; }
    li.active { background: #dbeafe; font-weight: bold; }
    li.dimmed { opacity: 0.55; }
  </style>
</head>
<body>
  <ul id="nav">
    <li class="active">Dashboard</li>
    <li>Reports</li>
    <li>Settings</li>
    <li>Help</li>
  </ul>
  <script src="https://code.jquery.com/jquery-3.7.1.min.js"></script>
  <script>
    $("#nav li:not(.active)").addClass("dimmed");
  </script>
</body>
</html>

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jQuery li:not(.active) — exclude a class (Try It)