HTML Code

<!DOCTYPE html>
<html lang="en">
<head>
  <title>:nth-last-of-type(2)</title>
  <style>
    body {
      font-family: Arial, sans-serif;
      margin: 16px;
      color: #0f172a;
    }

    span:nth-last-of-type(2) {
      background: #bbf7d0;
    }
  </style>
</head>
<body>
  <div>
    <span>A</span>
    <em>skip</em>
    <span>B</span>
    <span>C</span>
  </div>
</body>
</html>

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CSS :nth-last-of-type() — second-to-last